Cobalt in PDB 6p5z: Cobalt-Sirohydrochlorin-Bound S. Typhimurium Siroheme Synthase

All present enzymatic activity of Cobalt-Sirohydrochlorin-Bound S. Typhimurium Siroheme Synthase:
1.3.1.76; 2.1.1.107; 4.99.1.4;

The structure of Cobalt-Sirohydrochlorin-Bound S. Typhimurium Siroheme Synthase, PDB code: 6p5z was solved by J.M.Pennington, M.E.Stroupe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.34 / 2.26
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	59.601, 100.446, 146.4, 90, 90, 90
R / Rfree (%)	17.9 / 24.2

The structure of Cobalt-Sirohydrochlorin-Bound S. Typhimurium Siroheme Synthase also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Cobalt atom in the Cobalt-Sirohydrochlorin-Bound S. Typhimurium Siroheme Synthase (pdb code 6p5z). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Cobalt-Sirohydrochlorin-Bound S. Typhimurium Siroheme Synthase, PDB code: 6p5z:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Cobalt-Sirohydrochlorin-Bound S. Typhimurium Siroheme Synthase


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Cobalt-Sirohydrochlorin-Bound S. Typhimurium Siroheme Synthase within 5.0Å range: probe atom residue distance (Å) B Occ A:Co502 b:138.6 occ:1.00 CO A:F0X502 0.0 138.6 1.0 N17 A:F0X502 2.1 146.2 1.0 N27 A:F0X502 2.1 139.2 1.0 N16 A:F0X502 2.1 144.2 1.0 N14 A:F0X502 2.1 143.1 1.0 C28 A:F0X502 3.1 140.3 1.0 C3 A:F0X502 3.1 154.2 1.0 C18 A:F0X502 3.1 149.2 1.0 C8 A:F0X502 3.1 146.0 1.0 C26 A:F0X502 3.1 140.0 1.0 C13 A:F0X502 3.1 142.5 1.0 C5 A:F0X502 3.1 148.2 1.0 C10 A:F0X502 3.1 142.9 1.0 C29 A:F0X502 3.4 141.1 1.0 C9 A:F0X502 3.5 143.8 1.0 C25 A:F0X502 3.5 141.3 1.0 C4 A:F0X502 3.5 151.8 1.0 C19 A:F0X502 4.4 158.3 1.0 C06 A:F0X502 4.4 151.4 1.0 C30 A:F0X502 4.4 145.0 1.0 C31 A:F0X502 4.4 141.6 1.0 C12 A:F0X502 4.4 139.1 1.0 C11 A:F0X502 4.5 141.5 1.0 C2 A:F0X502 4.5 163.2 1.0 C07 A:F0X502 4.5 149.8 1.0

Cobalt binding site 2 out of 2 in the Cobalt-Sirohydrochlorin-Bound S. Typhimurium Siroheme Synthase


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Cobalt-Sirohydrochlorin-Bound S. Typhimurium Siroheme Synthase within 5.0Å range: probe atom residue distance (Å) B Occ A:Co503 b:136.7 occ:1.00 CO A:F0X503 0.0 136.7 1.0 N17 A:F0X503 2.1 132.1 1.0 N14 A:F0X503 2.1 132.1 1.0 N27 A:F0X503 2.1 138.2 1.0 N16 A:F0X503 2.1 134.2 1.0 NE2 A:HIS359 2.7 117.6 1.0 C18 A:F0X503 3.1 130.7 1.0 C13 A:F0X503 3.1 132.9 1.0 C8 A:F0X503 3.1 131.8 1.0 C10 A:F0X503 3.1 132.9 1.0 C28 A:F0X503 3.1 139.0 1.0 C26 A:F0X503 3.1 139.0 1.0 C3 A:F0X503 3.1 129.1 1.0 C5 A:F0X503 3.1 130.0 1.0 C29 A:F0X503 3.4 135.8 1.0 C25 A:F0X503 3.4 133.2 1.0 C9 A:F0X503 3.4 132.8 1.0 C4 A:F0X503 3.5 126.0 1.0 CD2 A:HIS359 3.5 111.0 1.0 NZ A:LYS270 3.7 131.0 1.0 CE1 A:HIS359 3.7 121.3 1.0 CE A:LYS270 4.3 131.0 1.0 C19 A:F0X503 4.3 132.6 1.0 C06 A:F0X503 4.4 129.1 1.0 C12 A:F0X503 4.4 134.6 1.0 C11 A:F0X503 4.4 136.9 1.0 C31 A:F0X503 4.4 144.0 1.0 C30 A:F0X503 4.4 139.3 1.0 C2 A:F0X503 4.5 132.4 1.0 C07 A:F0X503 4.5 129.8 1.0 CG A:HIS359 4.7 105.1 1.0 ND1 A:HIS359 4.7 115.3 1.0

J.M.Pennington, M.E.Stroupe. Siroheme Synthase Orients Substrates For Dehydrogenase and Chelatase Activities in A Single Active Site To Be Published.