Cobalt in PDB 6vyh: Cryo-Em Structure of SLC40/Ferroportin in Complex with Fab

The binding sites of Cobalt atom in the Cryo-Em Structure of SLC40/Ferroportin in Complex with Fab (pdb code 6vyh). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Cryo-Em Structure of SLC40/Ferroportin in Complex with Fab, PDB code: 6vyh:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Cryo-Em Structure of SLC40/Ferroportin in Complex with Fab


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Cryo-Em Structure of SLC40/Ferroportin in Complex with Fab within 5.0Å range: probe atom residue distance (Å) B Occ A:Co601 b:68.8 occ:1.00 OD2 A:ASP39 1.9 41.0 1.0 OD1 A:ASP39 2.1 41.0 1.0 CG A:ASP39 2.3 41.0 1.0 NE2 A:HIS43 2.4 43.1 1.0 CD2 A:HIS43 2.9 43.1 1.0 CE1 A:HIS43 3.6 43.1 1.0 CB A:ASP39 3.8 41.0 1.0 CG A:HIS43 4.2 43.1 1.0 OG A:SER147 4.5 21.2 1.0 ND1 A:HIS43 4.5 43.1 1.0 O A:ASP39 4.6 41.0 1.0 CA A:ASP39 4.7 41.0 1.0 C A:ASP39 4.8 41.0 1.0 NH2 A:ARG40 4.9 39.5 1.0

Cobalt binding site 2 out of 2 in the Cryo-Em Structure of SLC40/Ferroportin in Complex with Fab


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Cryo-Em Structure of SLC40/Ferroportin in Complex with Fab within 5.0Å range: probe atom residue distance (Å) B Occ A:Co602 b:96.8 occ:1.00 SG A:CYS326 2.1 77.5 1.0 CB A:CYS326 2.7 77.5 1.0 NE2 A:HIS508 2.9 46.6 1.0 CE1 A:HIS508 3.3 46.6 1.0 CA A:CYS326 3.8 77.5 1.0 CG1 A:VAL512 4.1 56.5 1.0 CD2 A:HIS508 4.1 46.6 1.0 O A:CYS326 4.5 77.5 1.0 C A:CYS326 4.5 77.5 1.0 ND1 A:HIS508 4.5 46.6 1.0 CE1 A:PHE509 4.6 47.2 1.0 CG2 A:VAL321 4.7 53.2 1.0 OG1 A:THR329 4.8 87.7 1.0 CB A:VAL512 4.9 56.5 1.0 CG2 A:VAL512 4.9 56.5 1.0 CD1 A:PHE509 4.9 47.2 1.0 N A:CYS326 4.9 77.5 1.0 CG A:HIS508 4.9 46.6 1.0

Y.Pan, Z.Ren, S.Gao, J.Shen, L.Wang, Z.Xu, Y.Yu, P.Bachina, H.Zhang, X.Fan, A.Laganowsky, N.Yan, M.Zhou. Structural Basis of Ion Transport and Inhibition in Ferroportin. Nat Commun V. 11 5686 2020.
ISSN: ESSN 2041-1723
PubMed: 33173040
DOI: 10.1038/S41467-020-19458-6