Cobalt in PDB 8c6z: Necrotic Enteritis Associated Clostridium P. Chitinase F8UNI4 in Complex with Inhibitor Bisdionin C

The structure of Necrotic Enteritis Associated Clostridium P. Chitinase F8UNI4 in Complex with Inhibitor Bisdionin C, PDB code: 8c6z was solved by Y.Bloch, S.N.Savvides, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.94 / 1.85
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	67.401, 67.401, 355.823, 90, 90, 90
R / Rfree (%)	19.7 / 22.3

The structure of Necrotic Enteritis Associated Clostridium P. Chitinase F8UNI4 in Complex with Inhibitor Bisdionin C also contains other interesting chemical elements:

Cadmium

(Cd)

2 atoms

The binding sites of Cobalt atom in the Necrotic Enteritis Associated Clostridium P. Chitinase F8UNI4 in Complex with Inhibitor Bisdionin C (pdb code 8c6z). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the Necrotic Enteritis Associated Clostridium P. Chitinase F8UNI4 in Complex with Inhibitor Bisdionin C, PDB code: 8c6z:

Cobalt binding site 1 out of 1 in the Necrotic Enteritis Associated Clostridium P. Chitinase F8UNI4 in Complex with Inhibitor Bisdionin C


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Necrotic Enteritis Associated Clostridium P. Chitinase F8UNI4 in Complex with Inhibitor Bisdionin C within 5.0Å range: probe atom residue distance (Å) B Occ A:Co701 b:41.4 occ:1.00 OD1 A:ASP232 1.8 40.3 1.0 OE2 A:GLU290 1.9 40.9 1.0 O A:GLY288 2.1 45.8 1.0 O A:HOH802 2.1 40.6 0.5 O A:HOH819 2.3 39.6 1.0 CD A:GLU290 2.9 40.8 1.0 CG A:ASP232 3.0 42.4 1.0 C A:GLY288 3.2 40.7 1.0 OE1 A:GLU290 3.3 41.7 1.0 CA A:GLY288 3.7 42.2 1.0 OD2 A:ASP232 3.7 46.0 1.0 OD1 A:ASN236 3.9 40.8 1.0 CB A:ASP232 4.1 40.2 1.0 N A:ALA289 4.3 38.7 1.0 CG A:GLU290 4.3 41.5 1.0 CA A:ASP232 4.4 45.2 1.0 O A:ASP232 4.4 45.6 1.0 CA A:ALA289 4.7 43.3 1.0 N A:GLU290 4.7 37.2 1.0 C A:ALA289 4.8 42.9 1.0 CG A:ASN236 4.9 43.0 1.0 C A:ASP232 4.9 42.1 1.0

Y.Bloch, E.Dierick, E.Goossens, S.N.Savvides. Contribution and Structural Characterization of Chitinases to Clostridium Perfringens Pathogenesis in Broilers To Be Published.