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Cobalt in PDB 9fxi: Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with SEN177
Enzymatic activity of Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with SEN177
All present enzymatic activity of Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with SEN177:
2.3.2.5;
2.3.2.5;
Protein crystallography data
The structure of Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with SEN177, PDB code: 9fxi
was solved by
G.Tassone,
C.Pozzi,
S.Mangani,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 74.87 / 3.06 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 86.435, 149.744, 95.652, 90, 97.1, 90 |
| R / Rfree (%) | 17.4 / 22.8 |
Other elements in 9fxi:
The structure of Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with SEN177 also contains other interesting chemical elements:
| Fluorine | (F) | 3 atoms |
Cobalt Binding Sites:
The binding sites of Cobalt atom in the Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with SEN177
(pdb code 9fxi). This binding sites where shown within
5.0 Angstroms radius around Cobalt atom.
In total 3 binding sites of Cobalt where determined in the Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with SEN177, PDB code: 9fxi:
Jump to Cobalt binding site number: 1; 2; 3;
In total 3 binding sites of Cobalt where determined in the Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with SEN177, PDB code: 9fxi:
Jump to Cobalt binding site number: 1; 2; 3;
Cobalt binding site 1 out of 3 in 9fxi
Go back to
Cobalt Binding Sites List in 9fxi
Cobalt binding site 1 out
of 3 in the Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with SEN177
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Cobalt with other atoms in the Co binding
site number 1 of Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with SEN177 within 5.0Å range:
|
Cobalt binding site 2 out of 3 in 9fxi
Go back to
Cobalt Binding Sites List in 9fxi
Cobalt binding site 2 out
of 3 in the Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with SEN177
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Cobalt with other atoms in the Co binding
site number 2 of Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with SEN177 within 5.0Å range:
|
Cobalt binding site 3 out of 3 in 9fxi
Go back to
Cobalt Binding Sites List in 9fxi
Cobalt binding site 3 out
of 3 in the Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with SEN177
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Cobalt with other atoms in the Co binding
site number 3 of Crystal Structure of Cobalt(II)-Substituted Double Mutant Y115E Y117E Human Glutaminyl Cyclase in Complex with SEN177 within 5.0Å range:
|
Reference:
G.Tassone,
C.Pozzi,
S.Mangani.
Metal Ion Binding to Human Glutaminyl Cyclase: A Structural Perspective. Int J Mol Sci V. 25 2024.
ISSN: ESSN 1422-0067
PubMed: 39125848
DOI: 10.3390/IJMS25158279
Page generated: Sun Jul 13 22:15:02 2025
ISSN: ESSN 1422-0067
PubMed: 39125848
DOI: 10.3390/IJMS25158279
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