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Cobalt in PDB 1fe2: Crystal Structure of Dihomo-Gamma-Linoleic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.

Enzymatic activity of Crystal Structure of Dihomo-Gamma-Linoleic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.

All present enzymatic activity of Crystal Structure of Dihomo-Gamma-Linoleic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.:
1.14.99.1;

Protein crystallography data

The structure of Crystal Structure of Dihomo-Gamma-Linoleic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1., PDB code: 1fe2 was solved by E.D.Thuresson, M.G.Malkowski, K.M.Lakkides, W.L.Smith, R.M.Garavito, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 3.00
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 182.190, 182.190, 103.230, 90.00, 90.00, 120.00
R / Rfree (%) 23.7 / 27.7

Cobalt Binding Sites:

The binding sites of Cobalt atom in the Crystal Structure of Dihomo-Gamma-Linoleic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1. (pdb code 1fe2). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total only one binding site of Cobalt was determined in the Crystal Structure of Dihomo-Gamma-Linoleic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1., PDB code: 1fe2:

Cobalt binding site 1 out of 1 in 1fe2

Go back to Cobalt Binding Sites List in 1fe2
Cobalt binding site 1 out of 1 in the Crystal Structure of Dihomo-Gamma-Linoleic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of Dihomo-Gamma-Linoleic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Co601

b:58.0
occ:1.00
CO A:COH601 0.0 58.0 1.0
NB A:COH601 2.0 58.0 1.0
ND A:COH601 2.0 58.0 1.0
NA A:COH601 2.0 58.0 1.0
NC A:COH601 2.0 58.0 1.0
NE2 A:HIS388 2.2 46.8 1.0
C4D A:COH601 3.0 58.0 1.0
C1C A:COH601 3.0 58.0 1.0
C4B A:COH601 3.0 58.0 1.0
C1D A:COH601 3.0 58.0 1.0
C1A A:COH601 3.0 58.0 1.0
C4A A:COH601 3.1 58.0 1.0
C1B A:COH601 3.1 58.0 1.0
CE1 A:HIS388 3.1 46.8 1.0
C4C A:COH601 3.1 58.0 1.0
CD2 A:HIS388 3.3 46.8 1.0
CHA A:COH601 3.3 58.0 1.0
CHC A:COH601 3.3 58.0 1.0
CHB A:COH601 3.4 58.0 1.0
CHD A:COH601 3.5 58.0 1.0
C3D A:COH601 4.3 58.0 1.0
ND1 A:HIS388 4.3 46.8 1.0
C2C A:COH601 4.3 58.0 1.0
C3B A:COH601 4.3 58.0 1.0
C3C A:COH601 4.3 58.0 1.0
C2B A:COH601 4.3 58.0 1.0
C2D A:COH601 4.4 58.0 1.0
CG A:HIS388 4.4 46.8 1.0
C2A A:COH601 4.4 58.0 1.0
C3A A:COH601 4.4 58.0 1.0
OE1 A:GLN203 4.5 52.7 1.0
CG1 A:VAL447 4.6 35.0 1.0
CE1 A:HIS207 4.7 51.8 1.0
NE2 A:HIS207 4.8 51.8 1.0

Reference:

E.D.Thuresson, M.G.Malkowski, K.M.Lakkides, C.J.Rieke, A.M.Mulichak, S.L.Ginell, R.M.Garavito, W.L.Smith. Mutational and X-Ray Crystallographic Analysis of the Interaction of Dihomo-Gamma -Linolenic Acid with Prostaglandin Endoperoxide H Synthases. J.Biol.Chem. V. 276 10358 2001.
ISSN: ISSN 0021-9258
PubMed: 11121413
DOI: 10.1074/JBC.M009378200
Page generated: Tue Jul 30 14:15:49 2024

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