Cobalt in PDB 1fof: Crystal Structure of the Class D Beta-Lactamase Oxa-10

All present enzymatic activity of Crystal Structure of the Class D Beta-Lactamase Oxa-10:
3.5.2.6;

The structure of Crystal Structure of the Class D Beta-Lactamase Oxa-10, PDB code: 1fof was solved by M.Paetzel, F.Danel, L.De Castro, S.C.Mosimann, M.G.P.Page, N.C.J.Strynadka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.79 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	48.400, 96.200, 125.700, 90.00, 90.00, 90.00
R / Rfree (%)	17.7 / 20.8

The binding sites of Cobalt atom in the Crystal Structure of the Class D Beta-Lactamase Oxa-10 (pdb code 1fof). This binding sites where shown within 5.0 Angstroms radius around Cobalt atom.
In total 2 binding sites of Cobalt where determined in the Crystal Structure of the Class D Beta-Lactamase Oxa-10, PDB code: 1fof:
Jump to Cobalt binding site number: 1; 2;

Cobalt binding site 1 out of 2 in the Crystal Structure of the Class D Beta-Lactamase Oxa-10


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 1 of Crystal Structure of the Class D Beta-Lactamase Oxa-10 within 5.0Å range: probe atom residue distance (Å) B Occ A:Co490 b:19.7 occ:1.00 O B:HOH575 2.2 12.0 1.0 OE2 A:GLU227 2.2 16.3 1.0 OE2 B:GLU190 2.2 24.3 1.0 O B:HOH547 2.2 16.9 1.0 OE1 A:GLU227 2.2 16.6 1.0 NE2 A:HIS203 2.3 10.6 1.0 CD A:GLU227 2.5 16.8 1.0 CD B:GLU190 3.0 22.3 1.0 CE1 A:HIS203 3.1 11.1 1.0 OE1 B:GLU190 3.1 26.3 1.0 CD2 A:HIS203 3.3 9.6 1.0 O B:HOH595 3.7 57.7 1.0 CG A:GLU227 4.0 16.4 1.0 O B:HOH616 4.1 31.5 1.0 CD1 A:LEU201 4.2 17.2 1.0 ND1 A:HIS203 4.2 9.0 1.0 CG B:GLU190 4.3 16.9 1.0 CG A:HIS203 4.4 10.8 1.0 O A:HOH534 4.4 19.2 1.0 NE1 A:TRP225 4.5 10.8 1.0 O B:HOH629 4.6 28.9 1.0 CB A:GLU227 4.9 15.9 1.0 CZ2 A:TRP225 4.9 11.7 1.0 CB A:LEU201 5.0 14.5 1.0

Cobalt binding site 2 out of 2 in the Crystal Structure of the Class D Beta-Lactamase Oxa-10


Mono view


Stereo pair view

A full contact list of Cobalt with other atoms in the Co binding site number 2 of Crystal Structure of the Class D Beta-Lactamase Oxa-10 within 5.0Å range: probe atom residue distance (Å) B Occ B:Co491 b:19.2 occ:1.00 OE2 A:GLU190 2.0 17.6 1.0 OE2 B:GLU227 2.1 13.9 1.0 O A:HOH649 2.1 13.0 1.0 NE2 B:HIS203 2.2 12.6 1.0 OE1 B:GLU227 2.3 11.4 1.0 O A:HOH648 2.3 17.6 1.0 CD B:GLU227 2.5 11.7 1.0 CD A:GLU190 3.0 17.1 1.0 CE1 B:HIS203 3.1 11.8 1.0 CD2 B:HIS203 3.2 11.0 1.0 OE1 A:GLU190 3.4 22.4 1.0 CG B:GLU227 4.0 11.9 1.0 CD2 B:LEU201 4.0 16.5 1.0 ND1 B:HIS203 4.2 13.0 1.0 O B:HOH548 4.2 22.0 1.0 O A:HOH574 4.3 26.1 1.0 CG B:HIS203 4.3 10.3 1.0 NE1 B:TRP225 4.4 9.7 1.0 CG A:GLU190 4.4 14.1 1.0 O A:HOH586 4.5 28.9 1.0 O A:HOH597 4.8 38.5 1.0 CB B:GLU227 4.9 13.4 1.0 CZ2 B:TRP225 4.9 13.4 1.0 CG B:LEU201 4.9 16.7 1.0

M.Paetzel, F.Danel, L.De Castro, S.C.Mosimann, M.G.Page, N.C.Strynadka. Crystal Structure of the Class D Beta-Lactamase Oxa-10. Nat.Struct.Biol. V. 7 918 2000.
ISSN: ISSN 1072-8368
PubMed: 11017203
DOI: 10.1038/79688